SENC 2025 - 20th Meeting of the Spanish Society of Neuroscience. 3-5 September. Las Palmas de Gran Canaria. Spain
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    SENC 2025 – 20th Meeting of the Spanish Society of Neuroscience. 3-5 September. Las Palmas de Gran Canaria. Spain SENC 2025 – 20th Meeting of the Spanish Society of Neuroscience. 3-5 September. Las Palmas de Gran Canaria. Spain SENC 2025 – 20th Meeting of the Spanish Society of Neuroscience. 3-5 September. Las Palmas de Gran Canaria. Spain SENC 2025 – 20th Meeting of the Spanish Society of Neuroscience. 3-5 September. Las Palmas de Gran Canaria. Spain
    •  
    • About ⇩
      • Welcome
      • Committees
      • Venue
      • Code of conduct of the SENC
      • Contact us
    • Scientific Info ⇩
      • Programme at a Glance
      • Main topics
    • Proposals Submission ⇩
      • Symposia submission
      • Abstracts Submission
      • Satellite events submission
    • Registration
    • Accommodation
    • Sponsorship

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    Symposium deadline submission extended until 1 December, 2025(clone)

      Abstract & fellowships deadline submission extended until March 20, 2025

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    S08 Multiscale approximations to understand microglia dysfunction in Alzheimer’s disease: from genes to cells, looking for new therapeutic targets
    Organizers
    Silvia De Santis. Instituto de Neurociencias de Alicante, CSIC-UMH
    Speakers
    Neuroinflammation in the pathogenesis of Alzheimer’s Disease
    Jose P. López-Atalaya. Instituto de Neurociencias de Alicante, CSIC-UMH
    Probing microglial contributions up- and down-stream of amyloid plaque deposition
    Giles E. Hardingham. University of Edinburgh
    Microglial dysfunction and senescence in Alzheimer’s disease brains
    Antonia Gutierrez. University of Malaga, IBIMA-Plataforma Bionand and CIBERNED
    Using diffusion-weighted magnetic resonance imaging to assess microstructural trajectories in a mouse model of Alzheimer’s disease
    Silvia De Santis. Instituto de Neurociencias de Alicante, CSIC-UMH
    Details
    This symposium will address the relevance of microglia states in the Alzheimer’s disease pathological course through a multi-scale, multi-species focus. The symposium will present state-of-the-art approximations, including single cell transcriptomics, cell profiling and microstructural neuroimaging in both animal models and human tissue.

    This symposium was co-funded by the Spanish State Research Agency (AEI/10.13039/501100011033), through the “Severo Ochoa” Center of Excellence grant to the IN (CEX2021-001165-S).

    S10 Unraveling Neurodevelopmental Disorders: from mouse models to human brain organoids
    Organizers
    Aixa V. Morales. Instituto Cajal, CSIC, Madrid, Spain
    Antonella Consiglio. Bellvitge Biomedical Research Institute (IDIBELL) University of Barcelona
    Speakers
    Cellular crosstalk in brain development
    Silvia Capello. Developmental Neurobiology Research Group, Max Planck Institute of Psychiatry, Munich (Germany)
    Enhancing neurogenesis and behavioral performance through partial reprogramming during development
    Daniel del Toro Ruiz, Dept. of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universidad de Barcelona
    Establishing human iPSC-derived brain organoids to model Tyrosine Hydroxylase Deficiency (THD) disease
    Antonella Consiglio. Bellvitge Biomedical Research Institute (IDIBELL) University of Barcelona (Spain)
    Animal models for understanding neurodevelopmental disorders in Lamb-Shaffer syndrome
    Aixa V. Morales. Instituto Cajal, CSIC, Madrid (Spain)
    Details
    The aim of this Symposium is to bring together researchers from the fields of stem cell reprogramming and brain organoids as well as experts in developmental biology and neurobiology to jointly discuss: i) the need of increasing our comprehension of molecular mechanism(s) underlying human neurodevelopment; ii) the challenges that exist in understanding the uniquely human aspects of NDDs; and iii) the design of new targeted disease-modifying therapies for NDDs. Advances in neural differentiation of pluripotent stem cells, including 3D brain organoids, and their contribution to the understanding of human brain development and disease, will be also discussed.
    Portuguese-Spanish Symposium

    Organizers
    Manuel Sánchez Malmierca, The Medical School & Institute of Neuroscience of Castilla y León (INCYL)

    Speakers
    Dopamine dynamics in the ventral striatum during flavor nutrient conditioning encode the learned energetic value of food
    Joaquim Alves da Silva, Champalimaud Foundation.

    Temporal rules of memory association
    Rosalina Fonseca, Instituto de Investigação e Inovação em Saúde – Universidade do Porto

    Temporal neuromodulation of cortical rhythmic activity
    Mavi Sánchez-Vives, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Barcelona

    State-dependent mechanisms of memory consolidation
    Azahara Oliva, Department of Neurobiology and Behavior, Cornell University

     

    S11 Neural Mechanisms for Internal State-Dependent Animal Behavior
    Organizers
    Nicolás Gutiérrez-Castellanos, Universidad de Valencia, UV
    Speakers
    The circadian control of hunger
    Amelia Douglas. Institute of Science and Technology Austria, IST
    TBD
    Andrew MacAskill. University College of London, UK
    Hypothalamic mechanisms for the regulation of innate behavior in health and disease
    Anne Petzold. European Neuroscience Institute Göttingen, ENI-G
    A hypothalamic node for the cyclical control of female sexual rejection
    Nicolás Gutiérrez-Castellanos. Universidad de Valencia, UV
    Details
    Animal behavior is not deterministic, that is, the same sensory input will not always lead to the same behavioral output. Instead, the behavioral response exhibited by an animal is strongly influenced by its internal state, which is determined by complex body-brain interactions that include metabolic and hormonal communication as well as past experiences. A clear example of this is found in food-seeking behavior. An animal doesn’t always eat a discovered food source. Instead, its decision depends on various contextual and internal signals, such as its metabolic state, energy cost, and potential threats from predators. Consequently, the animal may prioritize safety or rest over eating if it isn’t hungry, too tired, or frightened. Understanding the complexity of how the brain integrates sensory evidence with the internal state to shape behavior is central to this symposium, which aims to showcase cutting-edge research revealing a wide array of neural mechanisms that support these flexible decisions.
    S02. New approaches to understanding and restoring impaired sensory and motor functions caused by spinal cord injuries: the need for multidisciplinary therapies to combat highly complex diseases.
    Organizers
    Juan Aguilar. Hospital Nacional de Parapléjicos. SESCAM, Instituto de Investigación Sanitaria de Castilla-La Mancha. IDISCAM. Toledo. Spain.»
    Speakers
    Nanomaterials for the design of novel therapeutics in spinal cord injury
    María Concepción Serrano López-Terradas. Instituto de Ciencia de Materiales de Madrid, CSIC
    Neural reprogramming for sensory-motor integration after spinal cord injury.
    Carmelo Bellardita. Neural Circuitries and Motor Repair Laboratory, Department of Neuroscience. Copenhagen University.
    Harnessing sensory cortex modulation to restore function after spinal cord injury
    Kajana Satkunendrarajah. Department of Neurosurgery, Associate Director of Neuroscience Research Center, Medical College of Wisconsin»
    Deciphering role of inhibition in cortical reorganization after spinal cord injury.
    Juan Aguilar. Hospital Nacional de Parapléjicos. SESCAM, Instituto de Investigación Sanitaria de Castilla-La Mancha. IDISCAM. Toledo. Spain.
    Details
    Renowned experts will present cutting-edge techniques to analyze neural circuits and their roles in movement and sensory integration. The symposium will highlight methods such as neuromodulation, biomaterials, optical control, electrophysiology, and viral tracing to explore how brain-spinal pathways coordinate complex functions, emphasizing the integration of these advanced approaches to uncover the mechanisms driving movement generation and sensory processing.
    Honorary Lecture "María Teresa Miras Portugal": Carmen Guaza

    Beyond Neuroimmune Communication: Messengers and Cellular Targets
    Carmen Guaza, Instituto Cajal CSIC

    Details
    The interest in the functional interactions between the Nervous System and the Immune System, without overlooking the Neuroendocrine System, has shaped my scientific career from an integrative perspective in both physiological and pathological processes. Immune messengers, such as cytokines and chemokines are not only mediators of neuroinflammation but also essential for the protection and repair of the CNS. In multiple sclerosis (MS), the pathology on which we have focused through animal models, cell models and in MS itself we have identified new therapeutic targets in an effort to slow its progression. We found that the endogenous cannabinoid system plays a protective role in brain-immune cross-communication, targeting brain endothelial cells, microglia, astrocytes, oligodendrocytes, and their progenitors. The ability of microglia to acquire various activation states, -crucial for maintaining homeostasis, inflammation, and repair- is modulated by endocannabinoid signaling (eCBSS). This signaling system i) restores the inhibitory immune checkpoint CD200-CD200R which is key in neuron-microglia interaction and is disrupted at certain stages of MS ii) enhances the removal of myelin debris by microglía, thereby promoting the differentiation of oligodendrocyte progenitors cells (OPCs) and leading to remyelination in a viral model of MS iii) reduces proteoglycan accumulation and astrogliosis around plaques, facilitating remyelination and functional recovery in mice. In recent years, we have also become interested in the gut-brain axis and the characterization of the microbial profile in MS models.

    Presidential Lecture: Alfonso Araque

    Tripartite Synapses: Astrocyte regulation of synaptic function, network activity and animal behavior

    Alfonso Araque

    Iberian Neuroscience Lecture: Klaus-Armin Nave

    Oligodendrocytes in brain energy metabolism and Alzheimer’s disease

    Klaus-Armin Nave

    Details

    We found that oligodendrocytes, best known for making myelin and allowing fast saltatory impulse propagation in the CNS, also provide glycolysis products as metabolic support for fast spiking axons. Moreover, in white matter tracts, the myelin sheath is a dynamic compartment that continuously turns over. Thus, when glucose is limiting, myelinating oligodendrocytes can rapidly metabolize myelin-derived fatty acids to meet their own energy needs for survival and to prevent irreversible axon degeneration. Interestingly, oligodendrocytes and neurons both express and process the amyloid precursor protein (APP), but A peptides that are generated within oligodendrocytes contribute largely to the cortical and not the white matter plaque load in Alzheimer’s disease (AD) mouse models. This raises the question how oligodendroglial A is reaching neuronal plaques. In the aging brain, there is a gradual decline of myelin structural integrity, which is likely to affect myelin turnover and the metabolic coupling between oligodendrocytes and axons. This could be a risk factor for the onset of AD, because myelin dysfunction acts as a driver of amyloid plaque deposition in mice. This is in part due to the inhibition of microglia in phagocytosing A, which also identifies a new therapeutic target for delaying the onset of AD.

    Opening ceremony & Lecture: Isabel Fariñas

    The regulation of neural stem cell quiescence by a physical niche

    Isabel Fariñas. Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Departamento de Biología Celular, Biología Funcional y Antropología Física, Instituto de Biotecnología y Biomedicina (BioTecMed), Universidad de Valencia

    Details

    New neurons for highly plastic olfactory circuits are produced in the subependymal zone (SEZ) of the adult mammalian brain. Neural stem cells (NSCs) in this niche have access to a wide range of regulatory signals that promote continuous lifelong neurogenesis while preserving the stem cell pool. NSCs derive from radial glial cells, which are the primary embryonic progenitor type in the vertebrate brain, and inherit from them part of their transcriptional program, a bipolar elongated morphology with apico-basal polarity that allows for unique interactions with neighboring cell types, and markers associated with the astrocytic lineage. In contrast to their fetal counterparts, most adult NSCs remain in a quiescent state under physiological conditions. It is now widely accepted that NSCs in the SEZ exist in at least three states: quiescent (q), quiescent but prone to activation or primed (p), and activated (a), each characterized by unique and distinct transcriptional profiles. Transitions between states likely involve significant changes in cellular physiology tightly regulated by both intrinsic and extrinsic factors. We have found that entry into quiescence is associated with the deposition of specific extracellular matrix components and that adhesion to the matrix produced in response to pro-quiescent signals alone can induced a quiescent-like state in proliferative NSCs. This entry into quiescence depends on the RhoA-associated kinase ROCK and yes-associated protein (YAP) transcriptional activity. YAP/TAZ deletion in NSCs leads to the loss of ECM deposition and quiescence in vivo suggesting that they regulate the physical niche and a quiescence-associated gene expression program in response to mechanical cues.

    S09 Decoding Astrocyte-Neuron dynamics in brain function

    Organizers
    Gertrudis Perea; Instituto Cajal, CSIC, Madrid, Spain
    Speakers
    Astrocyte Kir4.1 expression level territorially controls excitatory transmission
    Dmitri Rusakov. UCL Queen Square Institute of Neurology, University College London, UK
    Astrocytes in higher brain function
    Inbal Goshen. The Edmond & Lily Safre Center for Brain Sciences, Jerusalem, Israel
    ControControl of dendritic computation by astrocytic D-serine and glycine signallingl
    Christian Henneberger. University of Bonn, Bonn, Germany
    Astrocyte tuning of social behaviors
    Gertrudis Perea. Instituto Cajal, CSIC, Madrid, Spain
    Details
    The symposium addresses the pivotal role of astrocytes play alongside neurons in shaping brain activity and complex behaviors. Astrocyte-neuron signaling represents a cutting-edge frontier in neuroscience, offering new insights into brain function that extend beyond traditional neuron-focused research. Astrocytes, a type of glial cell once considered merely supportive, are now recognized as active participants in the brain’s signaling processes. They modulate synaptic transmission, regulate blood flow, and play critical roles in neurovascular coupling and metabolic support to neurons. This symposium highlights cutting-edge discoveries by experts in the field revealing how astrocytes contribute also to higher brain functions, such as memory formation, learning, and emotional processing. Therefore, astrocyte-neuron «crosstalk» results essential for understanding the brain as an integrated system rather than as isolated parts.

    S07 Inhibitory circuits supporting network function

    Organizers
    Manuel Valero. Hospital del Mar Research Institute, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Barcelona, Spain
    Speakers
    Inhibitory circuits supporting developmental network dynamics
    Laura Modol. Hospital del Mar Research Institute, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Barcelona, Spain
    Cooperative action of interneuron classes supports the hippocampal function
    Manuel Valero, Hospital del Mar Research Institute, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Barcelona, Spain
    Role of interneurons in hippocampal network dynamics for learning and memory
    Antonio Fernández-Ruiz, Department of Neurobiology and Behavior. Cornell University, Ithaca (NY), US.
    Avalanche dynamics and  interneurons in the hippocampus during sleep following spatial learning
    Jozsef Csicsvari, Institute of Science and Technology Austria (ISTA), Klosterneuburg, Austria.
    Details
    Interneurons constitute a minority (15%) of cortical neurons but embody much of the neuronal genetic diversity. What evolutionary advantage might have driven this disproportionate diversity of interneurons? While the scientific community agrees that this diversity is essential for brain function, our ability to dissect their functional roles has been limited until recent years. In this symposium, we bring together four speakers from diverse disciplines, ranging from development to learning and memory, who exemplify the complexity and significance of integrating interneuronal diversity into the investigation of the neural mechanisms of behavior.

    S06 Cell fate in human neurodevelopment and disease

    Organizers
    Ana Uzquiano, Harvard University, Cambridge MA (USA)
    Sara Bizzotto, Imagine Institute, Inserm, Paris (France)
    Speakers
    Profiling and programming human in vitro neuronal diversity at single-cell resolution
    Hsiu-Chuan Lin. Centre for Genomic Regulation (CRG), Barcelona (Spain)
    Unlocking human cortical development through brain organoids
    Ana Uzquiano. Harvard University, Cambridge MA (USA)
    Identifying the first emergence of cortical disorder risks
    Gabriel Sanpere. Hospital del Mar Research Institute, Barcelona (Spain)
    Somatic mosaicism and cell lineages in human neurodevelopment and disease
    Sara Bizzotto. Imagine Institute, Inserm, Paris (France)
    Details
    In this symposium, we bring together complementary expertise in the neurodevelopment field to tackle specific questions about how the human brain is built, with a focus on cell fate in development, evolution and disease.

    S05 Excitatory and inhibitory mechanisms mediating dysfunction of neural circuits in neurodegeneration

    Organizers
    Arnaldo Parra-Damas, Universitat Autònoma de Barcelona
    Carlos Saura; Universitat Autònoma de Barcelona
    Speakers
    Impact of Aβ and tau pathologies on the transcriptomes of excitatory and inhibitory hippocampal neurons
    Arnaldo Parra-Damas. Universitat Autònoma de Barcelona.
    The role of hippocampal inhibition in memory deficits and functional recovery in Alzheimer’s disease mice
    Laure Verret. Université de Toulouse, Research Center on Animal Cognition, CNRS, Toulouse, France.
    Interneuron hyperexcitability is an early driver of hippocampal network imbalance in AD mice
    Ronald E. Van Kesteren. Vrije Universiteit Amsterdam, Netherlands
    Gene regulatory network alterations in Alzheimer’s disease at single-cell resolution
    Mireya Plass. Universitat de Barcelona & IDIBELL.
    Details
    Recent advances on cell-specific/single-cell profiling and modulation technologies have allowed detailed characterization of specific neural populations during physiological and pathological conditions. In neurodegenerative diseases, early altered activity of brain circuits is associated with transcriptional and pathophysiological changes affecting specific cell types and their interactions, including excitatory and inhibitory neurons. In Alzheimer’s disease (AD), excitatory neurons are the main degenerating population, although emerging evidence indicate that early dysfunction of GABAergic interneurons mediate excitatory/inhibitory (E/I) imbalance, leading to hyperexcitability and memory loss. In this symposium, we will present recent findings on the cellular and molecular mechanisms mediating E/I dysfunction of neural circuits in neurodegenerative diseases, including AD.

    S01 - Exploring the neural substrates of number sense: a perspective on genetics, behaviour and neural circuity

    Organizers
    José Vicente Torres Pérez. Department of Cellular Biology, Functional Biology and Physical Anthropology, University of Valencia, Spain
    Speakers
    Impact of cerebral asymmetry on quantitative abilities in zebrafish
    Maria Elena Miletto-Petrazzini, Department of Biomedical Sciences, University of Padova, Italy
    Exploring number sense deficit in Williams syndrome using zebrafish
    José Vicente Torres Pérez, Department of Cellular Biology, Functional Biology and Physical Anthropology, University of Valencia, Spain
    Genetic variance in numerosity and its association with working memory
    Caroline H Brennan, School of Biological and Behavioural Sciences, Queen Mary University of London, United Kingdom
    Single neuron coding of numerosity in chicks and zebrafish  developmental insights
    Mirko Zanon, Centre for Mind/Brain Sciences, University of Trento, Italy; and Translational Imaging Center, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, USA
    Details
    This symposium delves into a rapidly advancing area of cognitive neuroscience that remains underexplored: Numerical cognition or «Number sense», which refers to the innate ability to perceive and estimate quantities. This fundamental cognitive skill relies on an evolutionary conserved mechanism in all vertebrates. This symposium will uniquely combine insights from genetics, neurobiology, and comparative psychology to uncover the biological underpinnings of this vital cognitive process.

    S03 Neuron-Glia Metabolic Cooperation: Vital for Organismal Homeostasis and Health
    Organizers
    Juan P. Bolaños.  University of Salamanca, Salamanca, Spain
    Ángeles Almeida. CSIC Salamanca, Spain
    Speakers
    Metabolic flexibility of astrocytes in signaling and behavior
    Juan Pedro Bolaños.  University of Salamanca, Salamanca, Spain
    Metabolic flexibility of the Drosophila nervous system
    Stefanie Schirmeier. Technische Universität Dresden, Department of Biology, 01217 Dresden, Germany
    The astrocyte-to-neuron L-serine shuttle contributes to hippocampal plasticity
    Gilles Bonvento. Institut des Neurosciences Paris-Saclay, Paris, France
    Metabolic Support for Myelin Maintenance and Repair: The Role of Monocarboxylates and Their Transporters
    Vanja Tepavcevic. Laboratory of Comparative and Regenerative Neurobiology, Cavanilles Institute of Biodiversity and Evolutionary Biology, University of Valencia, Department of Cell Biology, Valencia, Spain
    Details
    Major advances have occurred in the understanding of the cellular and molecular determinants of brain energy metabolism highlighting a novel framework of well-regulated and dynamic metabolic dialogues between different cell types.  These comprise neuron-astrocyte coupling in the grey matter, and oligodendrocyte-axonal metabolic coupling in the white matter, the mechanisms of which are only beginning to be deciphered. The current conceptual understanding proposes that neuron-astrocyte and axon-oligodendrocyte partnerships function as distinct metabolic units, collaborating intricately to sustain brain function and promote the overall well-being of the organism.
    S15 Structuring the world: noise, probabilities, chunks and contexts
    Organizers
    Livia de Hoz. Charité-Universitätsmedizin Berlin Neuroscience, Germany
    Alejandro Tabas. Basque Center on Cognition, Brain and Language, San Sebastián, Spain
    Speakers
    Adaptive sound representation along the subcortico-cortical hierarchy depending on stimulus statistics
    Livia de Hoz. Charité-Universitätsmedizin Berlin Neuroscience, Germany
    Perceptual inference in the human subcortical auditory pathway
    Alejandro Tabas. Basque Center on Cognition, Brain and Language, San Sebastián, Spain
    Statistics, rules and probabilities: Different representational learning mechanisms across species
    József Fiser. Central European University, Budapest, Hungary
    Statistical learning and the learning curve: contextual inference and continual learning
    Máté Lengyel. University of Cambridge, UK
    Details
    In this symposium we will discuss our current understanding of how the brain chunks the sensory stream and parses it to a structured representation of perceptual objects. We will investigate the neural mechanisms responsible for this process, the neural structures and circuits implementing them, and the nature and structure of the final perceptual representation. We will address these questions from different sensory perspectives and levels of analysis, from subcortical processing of acoustic noise (de Hoz, mouse) and probabilistic stimuli (Tabas, human), to cognitive chunking (Fiser, bees, chicks, and humans), and context inference (Lengyel, computational models).
    S14 Gliotransmission and Metabolic Interplay
    Organizers
    Ana Covelo. Universidad de Vigo
    Speakers
    Ana Covelo. Universidad de Vigo
    Paola Bezzi. Universitéde Lausanne, Switzerland
    Cristina García-Cáceres. Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Munich, Munich, Germany
    Giovanni Marsicano. Bordeaux Neurocampus
    Details
    Astrocyte control of brain physiology is one of the hot topics in neuroscience. Although historically considered passive cells, accumulating evidence has revealed that astrocytes actively participate in regulating brain activity and behavior. They do this through metabolic processes but also by releasing neuroactive substances, termed gliotransmitters, that interact with neurons to regulate their activity. In this symposium we will review the most recent findings regarding how astrocytes regulate neuronal activity and synaptic plasticity in different brain circuits to impact animal behavior. The selected speakers are recognized experts in the field, each offering insights into different neuronal networks and expertise ranging from synaptic physiology to behavior.
    S13 Beyond Shaping Vision: Advances in Circuit Assembly and Plasticity
    Organizers
    Eloisa Herrera; Instituto de Neurociencias, CSIC, Alicante, Spain
    Robert Hindges; King’s College London, UK
    Speakers
    Rewiring Axonal Laterality of Retinothalamic Projections in Mice Enhances Binocular Vision and Predatory Behaviour
    Eloisa Herrera; Instituto de Neurociencias, CSIC, Alicante, Spain
    Early Visual Experience Elicits Cellular and Functional Plasticity in the Retina and Alters Behaviour
    Robert Hindges; King’s College London, UK
    Development and Plasticity of Crossmodal Visual-Auditory Circuits for Adaptive Behaviors
    Marta Nieto; Centro Nacional de Biotecnología, CSIC, Madrid, Spain
    Plasticity and stability: lessons from the visual cortex
    Tommaso Pizzorusso, Scoula Normale Superiore, Italy
    Details
    This symposium brings together leading experts to provide a comprehensive overview of current research on the visual system’s functionality and plasticity. lt presents recent views of how the building of the visual system and visual responses depend on complex circuital, cellular, and functional responses to environmental stimuli. It highlights important implications for our understanding and intervening in neurodevelopmental disorders.
    S12 Antibody-mediated mechanisms in autoimmune neurological disorders
    Organizers
    Estibaliz Maudes. ECTRIMS Postdoctoral fellow, Translational Neuroinflammation Group. Institut for Neuropathology, Neurology Clinic, Fraunhofer Institute, Göttingen Medical University, Göttingen, Germany.
    Josep Dalmau. Leader of the Pathogenesis of Autoimmune Neuronal Disorders Group. Fundació Clínic per la Recerca Biomèdica – Institut d’Investigacions Biomèdiques August Pi i Sunyer (FCRB-IDIBAPS), CaixaResearch Institute, University of Barcelona, Spain. Adjunct Professor of Neurology at the University of Pennsylvania, USA.
    Speakers
    From patients’ symptoms to the discovery of antibody-mediated synaptic disorders
    Josep Dalmau. Leader of the Pathogenesis of Autoimmune Neuronal Disorders Group. Fundació Clínic per la Recerca Biomèdica – Institut d’Investigacions Biomèdiques August Pi i Sunyer (FCRB-IDIBAPS), CaixaResearch Institute, University of Barcelona, Spain. Adjunct Professor of Neurology at the University of Pennsylvania, USA.
    Animal models of autoimmune encephalitis and what we can learn for clinical management
    Estibaliz Maudes. ECTRIMS Postdoctoral fellow, Translational Neuroinflammation Group. Institut for Neuropathology, Neurology Clinic, Fraunhofer Institute, Göttingen Medical University, Göttingen, Germany.
    Cross-talk between antibodies and innate immunity in encephalitis
    Marianna Spatola. Junior leader by La Caixa Foundation. Fundació Clínic per la Recerca Biomèdica – Institut d’Investigacions Biomèdiques August Pi i Sunyer (FCRB-IDIBAPS), CaixaResearch Institute, University of Barcelona, Spain.
    Antibody-mediated changes in neuronal circuits and memory
    Albert Compte. Leader of the Theoretical Neurobiology of Cortical Circuits Group. Fundació Clínic per la Recerca Biomèdica – Institut d’Investigacions Biomèdiques August Pi i Sunyer (FCRB-IDIBAPS), Spain.
    Details
    This symposium will explore the expanding role of neural cell-surface antibodies in neurological diseases. These antibodies, targeting ion channels, receptors, and synaptic proteins, are linked to a broad range of neurological symptoms. Notably, N-methyl-D-aspartate receptor (NMDAR) antibodies are commonly found in patients with psychiatric symptoms, memory deficits, and other neurological alterations. Advances in neuroimmunology have helped elucidate antibody-mediated encephalitis mechanisms using cellular and animal models. Imaging and electrophysiological studies have detailed how autoantibodies interact with cell-surface proteins, disrupting their function. Meanwhile, passive transfer models have demonstrated the pathogenicity of these antibodies in vivo, and emerging active immunization models provide deeper insights into disease immunobiology and potential therapies.
    Beyond direct receptor or synaptic protein effects, neural cell-surface antibodies can also trigger innate immune responses, including microglial activation, which may contribute to antigen loss and neuronal dysfunction. However, the mechanisms driving the diversity of clinical phenotypes remain poorly understood, emphasizing the need for systematic profiling of patients’ antibodies. Additionally, these autoantibodies serve as powerful tools for studying cognitive processes, with recent findings indicating their impact on neuronal circuits involved in working memory. This symposium will present a comprehensive review of antibody-mediated mechanisms in immune-mediated neurological disorders, offering valuable insights into both disease pathogenesis and potential therapeutic advancements.
    S04 Understanding Habenulae function in Emotional Behavior
    Organizers
    Joaquín Piriz, Achúcarro
    Edgar Soria-Gómez; Achucarro
    Speakers
    Edgar Soria-Gómez, Achucarro
    Susanna Molas, University of Colorado Boulder, USA
    Inés Ibañez-Tallón, The Rockefeller University, USA
    Christophe Proulx, CERVO, Université Laval, Canada
    Details
    The symposium aims to elucidate how the habenula contributes to the encoding of motivation and emotion across different behavioral states. The ultimate goal is to identify molecular targets that modulate these processes in physiology and pathology.