Organizers
Gertrudis Perea; Instituto Cajal, CSIC, Madrid, Spain
Speakers
Astrocyte Kir4.1 expression level territorially controls excitatory transmission
Dmitri Rusakov. UCL Queen Square Institute of Neurology, University College London, UK
Astrocytes in higher brain function
Inbal Goshen. The Edmond & Lily Safre Center for Brain Sciences, Jerusalem, Israel
ControControl of dendritic computation by astrocytic D-serine and glycine signallingl of dendritic computation by astrocytic D-serine and glycine signalling
Christian Henneberger. University of Bonn, Bonn, Germany
Astrocyte tuning of social behaviors
Gertrudis Perea. Instituto Cajal, CSIC, Madrid, Spain
Details
The symposium addresses the pivotal role of astrocytes play alongside neurons in shaping brain activity and complex behaviors. Astrocyte-neuron signaling represents a cutting-edge frontier in neuroscience, offering new insights into brain function that extend beyond traditional neuron-focused research. Astrocytes, a type of glial cell once considered merely supportive, are now recognized as active participants in the brain’s signaling processes. They modulate synaptic transmission, regulate blood flow, and play critical roles in neurovascular coupling and metabolic support to neurons. This symposium highlights cutting-edge discoveries by experts in the field revealing how astrocytes contribute also to higher brain functions, such as memory formation, learning, and emotional processing. Therefore, astrocyte-neuron «crosstalk» results essential for understanding the brain as an integrated system rather than as isolated parts.

Organizers
Manuel Valero. Hospital del Mar Research Institute, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Barcelona, Spain
Speakers
Inhibitory circuits supporting developmental network dynamics
Laura Modol. Hospital del Mar Research Institute, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Barcelona, Spain
Cooperative action of interneuron classes supports the hippocampal function
Manuel Valero, Hospital del Mar Research Institute, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Barcelona, Spain
Role of interneurons in hippocampal network dynamics for learning and memory
Antonio Fernández-Ruiz, Department of Neurobiology and Behavior. Cornell University, Ithaca (NY), US.
Avalanche dynamics and  interneurons in the hippocampus during sleep following spatial learning
Jozsef Csicsvari, Institute of Science and Technology Austria (ISTA), Klosterneuburg, Austria.
Details
Interneurons constitute a minority (15%) of cortical neurons but embody much of the neuronal genetic diversity. What evolutionary advantage might have driven this disproportionate diversity of interneurons? While the scientific community agrees that this diversity is essential for brain function, our ability to dissect their functional roles has been limited until recent years. In this symposium, we bring together four speakers from diverse disciplines, ranging from development to learning and memory, who exemplify the complexity and significance of integrating interneuronal diversity into the investigation of the neural mechanisms of behavior.

Organizers
Ana Uzquiano, Harvard University, Cambridge MA (USA)
Sara Bizzotto, Imagine Institute, Inserm, Paris (France)
Speakers
Profiling and programming human in vitro neuronal diversity at single-cell resolution
Hsiu-Chuan Lin. Centre for Genomic Regulation (CRG), Barcelona (Spain)
Unlocking human cortical development through brain organoids
Ana Uzquiano. Harvard University, Cambridge MA (USA)
Identifying the first emergence of cortical disorder risks
Gabriel Sanpere. Hospital del Mar Research Institute, Barcelona (Spain)
Somatic mosaicism and cell lineages in human neurodevelopment and disease
Sara Bizzotto. Imagine Institute, Inserm, Paris (France)
Details
In this symposium, we bring together complementary expertise in the neurodevelopment field to tackle specific questions about how the human brain is built, with a focus on cell fate in development, evolution and disease.

Organizers
Arnaldo Parra-Damas, Universitat Autònoma de Barcelona
Carlos Saura; Universitat Autònoma de Barcelona
Speakers
Impact of Aβ and tau pathologies on the transcriptomes of excitatory and inhibitory hippocampal neurons
Arnaldo Parra-Damas. Universitat Autònoma de Barcelona.
The role of hippocampal inhibition in memory deficits and functional recovery in Alzheimer’s disease mice
Laure Verret. Université de Toulouse, Research Center on Animal Cognition, CNRS, Toulouse, France.
Interneuron hyperexcitability is an early driver of hippocampal network imbalance in AD mice
Ronald E. Van Kesteren. Vrije Universiteit Amsterdam, Netherlands
Gene regulatory network alterations in Alzheimer’s disease at single-cell resolution
Mireya Plass. Universitat de Barcelona & IDIBELL.
Details
Recent advances on cell-specific/single-cell profiling and modulation technologies have allowed detailed characterization of specific neural populations during physiological and pathological conditions. In neurodegenerative diseases, early altered activity of brain circuits is associated with transcriptional and pathophysiological changes affecting specific cell types and their interactions, including excitatory and inhibitory neurons. In Alzheimer’s disease (AD), excitatory neurons are the main degenerating population, although emerging evidence indicate that early dysfunction of GABAergic interneurons mediate excitatory/inhibitory (E/I) imbalance, leading to hyperexcitability and memory loss. In this symposium, we will present recent findings on the cellular and molecular mechanisms mediating E/I dysfunction of neural circuits in neurodegenerative diseases, including AD.

Organizers
José Vicente Torres Pérez. Department of Cellular Biology, Functional Biology and Physical Anthropology, University of Valencia, Spain
Speakers
Impact of cerebral asymmetry on quantitative abilities in zebrafish
Maria Elena Miletto-Petrazzini, Department of Biomedical Sciences, University of Padova, Italy
Exploring number sense deficit in Williams syndrome using zebrafish
José Vicente Torres Pérez, Department of Cellular Biology, Functional Biology and Physical Anthropology, University of Valencia, Spain
Genetic variance in numerosity and its association with working memory
Caroline H Brennan, School of Biological and Behavioural Sciences, Queen Mary University of London, United Kingdom
Single neuron coding of numerosity in chicks and zebrafish  developmental insights
Mirko Zanon, Centre for Mind/Brain Sciences, University of Trento, Italy; and Translational Imaging Center, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, USA
Details
This symposium delves into a rapidly advancing area of cognitive neuroscience that remains underexplored: Numerical cognition or «Number sense», which refers to the innate ability to perceive and estimate quantities. This fundamental cognitive skill relies on an evolutionary conserved mechanism in all vertebrates. This symposium will uniquely combine insights from genetics, neurobiology, and comparative psychology to uncover the biological underpinnings of this vital cognitive process.